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Title: The Role of Aldosterone in Hypertension and its Clinical Consequences
4. Explain, with specific examples, how abnormal regulation or action of aldosterone can lead to hypertension. You should list at least three clinical conditions that result from abnormal regulation of the action of aldosterone.
ANSWER (about 400-500 words):
5. CKD also causes hypertension due to widespread endothelial dysfunction. Describe and discuss 2 different mechanisms by which CKD is associated with widespread endothelial dysfunction (nitric oxide deficiency). ANSWER (about 400-500 words):
6. Eventually APOL-1 was identified as a gene that puts African Americans at risk for certain types of renal disease. Was there selection pressure for this gene? If so, what was it? ANSWER (about 400-500 words):
7.Discuss three different mechanisms which contribute to the pathogenesis of salt-sensitive
hypertension and indicate potential interactions between theluvse mechanisms.
ANSWER (about 400-500 words):
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