“The Role of the Central Cholinergic System in Treating Alzheimer’s Disease: Identifying the Brain Region Responsible for Therapeutic Effect”

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“The Role of the Central Cholinergic System in Treating Alzheimer’s Disease: Identifying the Brain Region Responsible for Therapeutic Effect”

Hi,
Thank you for your post. I’d like to pose a question to you and the class:
Neuropathologic features associated with basal forebrain atrophy in Alzheimer disease | Neurology
A 72-year-old man recently diagnosed with Alzheimer disease started a therapy with a drug that acts mainly on the central cholinergic system. Which of the following brain regions was most likely involved in the therapeutic effect of the drug in this patient?
A. Nucleus basalis of Meynert
B. Central raphe nucleus
C. Locus ceruleus
D. Substantia nigra
E. Amygdala
F. Nucleus tractus solitarius
Please provide rationalfjkes for your selected answer choice.
Best,
Reply

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