Swamped with your writing assignments? Take the weight off your shoulder!
Submit your assignment instructions
This assignment is about: The role of drug transporter pharmacogenetics in affecting drug (Rosuvastatin) disposition and bioavailability.
Explore the effect of this polymorphism on the transporter expression and/or functionality and Explain
the extent to which the transporter pharmacogenetics affects any aspect of the pharmacokinetics (ADME)
Rosuvastatin: Effects of polymorphisms in the ABCG2 gene on Rosuvastatin
General information:
Drug class: HMG-CoA Reductase Inhibitor
Dosage forms: Oral Tablet (5 mg, 10 mg, 20 mg, 40 mg), Oral Capsule (5 mg, 10 mg, 20
mg, 40 mg).
Indication: hyperlipidemia, Disorder of cardiovascular system, primary
prophylaxis, familial hypercholesterolemia, homozygous, hypertriglyceridemia,
mixed dyslipidemia
MOA: competitively inhibit conversion of HMG-CoA to mevalonate, an early
rate-limiting step in cholesterol synthesis. A compensatory increase in LDL
receptors, which bind and remove circulating LDL-cholesterol, results. Production
of LDL-cholesterol can also decrease because of decreased production of
VLDL-cholesterol or increased VLDL removal by LDL receptors.
Pharmacokinetics of Rosuvastatin:
Absorption: F = 20%, food slows absorption
Distribution: Vd = 134 L; 88% protein bound
Metabolism: minimal hepatic
Excretion: Fecal 90% with half-life of 13-20 hours
What is ABCG2 polymorphism?
Drug transporter aka BCRP, an efflux pump
Usually expressed in tissues: kidney, brain, liver, placenta and the
small intestine.
Plays the role as a tissue barrier that limits the absorption in the
GI, BBB & placenta.
Xenobiotic substrates are excreted primarily in the bile & urine
Questions that you should do for this assignment:
1/The Role of ABCG2 Pharmacogenomics affecting
Rosuvastatin Bioavailability
2/Explain the role of drug transporter pharmacogenetics in affecting
drug disposition ( rosuvastatin ) and bioavailability.
3/Effects of the rs2231142 on the Pharmacokinetics
of Rosuvastatin
4/Explore the effect of this polymorphism on the transporter
expression and/or functionality
Please DO NOT forget to write the work references.
Swamped with your writing assignments? Take the weight off your shoulder!
Submit your assignment instructions
Place this order or similar order and get exceptional paper written by our team of experts at an affordable price
